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NEWS

2025

December 1, 2025

Andrew Makarov, MPhil joined the Boettcher Lab as a Research Associate and soon PhD student.
Welcome to the team, Andrew !!! 

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September 8, 2025

Jonas Fullin successfully defended his PhD thesis.
Congratulations, Jonas !!! 

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June 5, 2025

PAPER ALERT !!!
Nancy Klemm's paper entitled The Prolonged Half-Life of the p53 Missense Variant R248Q Promotes Accumulation and Heterotetramer Formation with Wild-Type p53 to Exert the Dominant-Negative Effect has been published in Cancer Research.

Congratulations, Nancy !!! 

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May 14, 2025

Nancy Klemm successfully defended her PhD thesis.
Congratulations, Nancy !!! 

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2024

November 20, 2024

Grant awarded by the Jacques and Gloria Gossweiler Foundation !!! 
This generous financial contribution will support our ongoing efforts to study the pathogenesis of therapy-related myeloid malignancies.

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November 6, 2024

Congratulations to Roman Schimmer for receiving a 2024 ASH Abstract Achievement Award !!!

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November 6, 2024

Congratulations to Roman Schimmer for being selected to present his abstract entitled Somatic TP53 Mutations Rescue the Hematopoietic Stem and Progenitor Cell Defect at the Expense of Increased Risk for Myeloid Malignancies in ERCC6L2-Associated Inherited Bone Marrow Failure Syndrome as oral presentation during the 66th ASH Annual Meeting and Exposition, taking place from December 7-10, 2024, in San Diego, CA, USA.

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November 6, 2024

Congratulations to Jonas Fullin for being selected to present his abstract entitled The Pathogenesis of Therapy-Related Myeloid Neoplasms from TP53-Mutant Clonal Hematopoiesis as oral presentation during the 66th ASH Annual Meeting and Exposition, taking place from December 7-10, 2024, in San Diego, CA, USA.

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October 15, 2024

Congratulations to Roman Schimmer for being selected to present his abstract entitled Somatic TP53 Mutations Rescue the Hematopoietic Stem and Progenitor Cell Defect at the Expense of Increased Risk for Myeloid Malignancies in ERCC6L2-Associated Inherited Bone Marrow Failure Syndrome as oral presentation during the 3rd ESH-EBMT-EHA-IPIG Translational Research Conference: Bone Marrow Failure and Leukaemia Predisposition Syndromes, taking place from November 15-17, 2024, in Paris, France.

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October 4, 2024

Grant awarded by the ETH Zurich Lymphoma Challenge !!!
Together with Prof. Niko Beerenwinkel and his team we will study Hematopoietic Stem and Progenitor Cell-State–Cell-Fate Trajectories during the Development of TP53-mutant Leukemia: From Pathobiology to Clinical Application.

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February 14, 2024

PAPER ALERT !!!
Jan Mueller and Roman Schimmer published their paper entitled Targeting the mevalonate or Wnt pathways to overcome CAR T-cell resistance in TP53-mutant AML cells in EMBO Molecular Medicine.
And it even made it on the cover!

Congratulations, Jan & Roman !!! 

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February 1, 2024

Melissa Lock, MSc joined the Boettcher Lab as a PhD student.
Welcome to the team, Melissa !!! 

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2023

November 2, 2023

Congratulations to Jan Mueller for receiving a 2023 ASH Abstract Achievement Award !!!

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November 2, 2023

Congratulations to Jan Mueller for being selected to present his abstract entitled TP53 Deficiency in AML Confers Resistance to CAR T-Cells That Can be Overcome By Targeting the Cholesterol or Wnt Pathways as oral presentation during the 65th ASH Annual Meeting and Exposition, taking place from December 9-12, 2023, in San Diego, CA, USA.

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2022

November 18, 2022

Congratulations to Roman Schimmer for receiving the Ellermann Young Talent Award in Hematology 2022 !!!

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June 14, 2022

PAPER ALERT !!!
Roman Schimmer published his paper entitled TP53 mutations confer resistance to hypomethylating agents and BCL-2 inhibition in myeloid neoplasms in Blood Advances.

Congratulations, Roman !!! 

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©2025  Boettcher Lab at University of Zurich and University Hospital of Zurich

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